一、基本信息
毛凯，男，1984年9月出生，河北省石家庄市人，教授，博士生导师。
二、学习经历
2003年9月-2007年7月在北京大学生物科学专业学习，获理学学士学位；
2008年8月-2013年12月在美国密歇根大学分子生物学专业学习，获博士学位。
三、工作经历
2014年1月至今，在美国哈佛大学医学院/麻省总医院Gary Ruvkun实验室从事博士后研究。
四、研究方向
以秀丽线虫为模式生物，探讨衰老的机制、相关细胞和整体效应以及相关人类疾病的机制，主要研究方向为：1）线粒体功能障碍诱导线虫抗病毒RNAi反应的分子机制，包括探讨解旋酶RAD-26/ARIP4、肌醇-多磷酸在抗病毒RNAi反应中的作用和机制以及线粒体DNA 的保养、RNAi 的激活与衰老的关系；2）探索MDT-15/NHR-45 介导的免疫反应的分子机制，包括寻找激活NHR-45 的小分子配体、构建自主激活免疫反应的合成回路、和探索MDT-15 调控转录的分子机制；3）探索线粒体应激反应的分子机制，包括控制线虫食物避免行为的肠源性信号传导、线粒体应激反应中可能存在的负面影响、以及进一步丰富线粒体突变体遗传资源。
五、主持项目情况
2014年-2018年，主持Damon Runyon Cancer Research Foundation项目Damon Runyon Postdoctoral Fellowship，到位经费$236k USD。
六、主要学术成果
1.Kai Mao;Fei Ji; Peter Breen; Aileen Sewell; Min Han; Ruslan Sadreyev; Gary Ruvkun* ; Mitochondrial dysfunction in C. elegans activates mitochondrial relocalization and nuclear hormone receptor-dependent detoxification genes.Cell Metabolism, 2019, 29(5): 1182-1191.
2.Kai Mao; Peter Breen; Gary Ruvkun*; Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response,PLoS Biology, 2020, 18(12): e3000996.
3.Kai Mao; Ke Wang; Xu Liu; Daniel J Klionsky* ; The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy,Developmental Cell, 2013, 26(1): 9-18.
4.Kai Mao; Leon H Chew; Yuko Inoue-Aono; Heesun Cheong; Usha Nair; Hana Popelka; Calvin K Yip; Daniel J Klionsky*; Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation,Proceedings of the National Academy of Sciences of the United States of America, 2013, 110(31): E2875-84.
5.Kai Mao; Ke Wang; Mantong Zhao; Tao Xu; Daniel J Klionsky* ; Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae,Journal of Cell Biology, 2011, 193(4): 755-67.
6.Kai Mao; Daniel J Klionsky*; Xenophagy: A battlefield between host and microbe, and a possible avenue for cancer treatment,Autophagy,2017, 13(2): 223-224.
7. Xu Liu# ;Kai Mao#; Angela Y H Yu; Amin Omairi-Nasser; Jotham Austin 2nd; Benjamin S Glick; Calvin K Yip; Daniel J Klionsky*; The Atg17-Atg31-Atg29 Complex Coordinates with Atg11 to Recruit the Vam7 SNARE and Mediate Autophagosome-Vacuole Fusion,Current Biology,2016, 26(2): 150-160.
8.Kai Mao#; Xu Liu#; Yuchen Feng; Daniel J Klionsky*; The progression of peroxisomal degradation through autophagy requires peroxisomal division,Autophagy,2014, 10(4): 652-61.
9. Joseph Ochaba; Tamás Lukacsovich; George Csikos; Shuqiu Zheng; Julia Margulis; Lisa Salazar;Kai Mao; Alice L Lau; Sylvia Y Yeung; Sandrine Humbert; Frédéric Saudou; Daniel J Klionsky; Steven Finkbeiner; Scott O Zeitlin; J Lawrence Marsh; David E Housman* ; Leslie M Thompson; Joan S Steffan* ; Potential function for the Huntingtin protein as a scaffold for selective autophagy,Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(47): 16889-94.
10. Natsuko Jin;Kai Mao; Yui Jin; Gela Tevzadze; Emily J Kauffman; Sujin Park; Dave Bridges; Robbie Loewith; Alan R Saltiel; Daniel J Klionsky; Lois S Weisman* ; Roles for PI(3,5)P2 in nutrient sensing through TORC1,Molecular Biology of the Cell, 2014, 25(7): 1171-85.
11.Kai Mao; Daniel J Klionsky* ; Participation of mitochondrial fission
during mitophagy,Cell Cycle, 2013, 12(19): 3131-2.
12.Kai Mao; Daniel J Klionsky* ; Mitochondrial fission facilitates mitophagy in Saccharomyces cerevisiae, Autophagy, 2013, 9(11): 19000-1.
13.Kai Mao; Leon H Chew; Calvin K Yip; Daniel J Klionsky* ; The role of Atg29 phosphorylation in PAS assembly, Autophagy, 2013, 9(12): 2178-9.
14. Stephen E Kaiser; Yu Qiu; Julie E Coats;Kai Mao; Daniel J Klionsky; Brenda A Schulman*; Structures of Atg7-Atg3 and Atg7-Atg10 reveal noncanonical mechanisms of E2 recruitment by the autophagy E1,Autophagy, 2013, 9(5): 778-80.
15. Stephen E Kaiser;Kai Mao; Asad M Taherbhoy; Shanshan Yu; Jennifer L Olszewski; David M Duda; Igor Kurinov; Alan Deng; Timothy D Fenn; Daniel J Klionsky; Brenda A Schulman* ; Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures,Nature Structural & Molecular Biology, 2012, 19(12): 1242-9.
16. Melinda A Lynch-Day;Kai Mao; Ke Wang; Mantong Zhao; Daniel J Klionsky* ; The role of autophagy in Parkinson's disease,Cold Spring Harbor Perspectives in Medicine, 2012, 2(4): a009357.
17. Ke Wang; Zhifen Yang; Xu Liu;Kai Mao; Usha Nair; Daniel J Klionsky*; Phosphatidylinositol 4-kinases are required for autophagic membrane trafficking,Journal of Biological Chemistry, 2012, 287(45): 37964-72.
18.Kai Mao; Daniel J Klionsky*; AMPK activates autophagy by phosphorylating ULK1,Circulation Research, 2011, 108(7): 787-8.
19.Kai Mao; Daniel J Klionsky* ; MAPKs regulate mitophagy in Saccharomyces cerevisiae,Autophagy, 2011, 7(12): 1564-5.
20. Tomotake Kanki; Ke Wang; Misuzu Baba; Clinton R Bartholomew; Melinda A Lynch-Day; Zhou Du; Jiefei Geng;Kai Mao; Zhifen Yang; Wei-Lien Yen; Daniel J Klionsky* ; A genomic screen for yeast mutants defective in selective mitochondria autophagy,Molecular Biology of the Cell, 2009, 20(22) : 4730-8.
21. Chong Liu;Kai Mao; Meng Zhang; Zhaogang Sun; Weizhe Hong; Chuanyou Li; Bo Peng; Zengyi Chang*; The SH3-like domain switches its interaction partners to modulate the repression activity of mycobacterial iron-dependent transcription regulator in response to metal ion fluctuations,Journal of Biological Chemistry, 2008, 283(4): 2439-53.
22. Daniel J Klionsky* ;Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition),Autophagy, 2021, 17(1): 1-382.（主要参与编著人）
23. Daniel J Klionsky* ; Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition),Autophagy, 2016, 12(1): 1-222.（主要参与编著人）
24. Daniel J Klionsky*; Guidelines for the use and interpretation of assays for monitoring autophagy, Autophagy, 2012, 8(4): 445-544.（主要参与编著人）
七、获奖情况
1. 2013年，获国家优秀自费留学生奖学金；
2. 2014年，获美国Damon Runyon Cancer Research Foundation Damon Runyon Postdoctoral Fellowship。
八、招生学科
生物学（博士、硕士），生物医学（博士、硕士）
九、联系方式
地址：陕西杨凌江南游戏中心
邮编：712100
邮件：maokai@molbio.mgh.harvard.edu
