一、基本信息
毛凯，男，1984年9月出生，河北人，教授，博士生导师。
二、科研履历
2022年至今，江南游戏中心教授。
2014年-2021年，美国哈佛大学医学院/麻省总医院，博士后。
2008年-2013年，美国密歇根大学分子细胞发育生物学专业，博士学位。
2003年-2007年，北京大学生物科学专业，理学学士学位。
三、研究方向
以秀丽隐杆线虫为模式生物，探讨线粒体通过调控免疫反应影响衰老的分子机制。我们的主要研究方向包括：1）自发性的线粒体DNA突变与老年慢性炎症的关系；2）线粒体功能障碍诱发抗病毒RNAi的机理；3）腺苷脱氨酶ADAR介导的RNA编辑对衰老的影响。
四、主要学术成果(Research Article)
1.Xu W, Sun Y, Breen P, Ruvkun G*, &Mao K*. Caenorhabditis elegans inositol hexaphosphate pathways couple to RNA interference and pathogen defense.PNAS.121(49):e2416982121
2.Mao K, Breen P, & Ruvkun G* (2022) The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways.PNAS.119(49):e2215966119
3.Mao K, Breen P, & Ruvkun G* (2020) Mitochondrial dysfunction induces RNA interference in C. elegans through a pathway homologous to the mammalian RIG-I antiviral response.Plos Biol.18(12):e3000996
4.Mao K, Ji F, Breen P, Sewell A, Han M, Sadreyev R, & Ruvkun G* (2019) Mitochondrial dysfunction inC. elegansactivates mitochondrial relocalization and nuclear hormone receptor-dependent detoxification genes.Cell Metab.29(5):1182-91
5.Liu X#,Mao K#, Yu AY, Omairi-Nasser A, Austin J 2nd, Glick BS, Yip CK, & Klionsky DJ* (2016) The Atg17-Atg31-Atg29 complex coordinates with Atg11 to recruit the Vam7 SNARE and mediate autophagosome-vacuole fusion.Curr. Biol.26(2):150-60 (# equal contribution)
6.Ochaba J, Lukacsovich T, Csikos G, Zheng S, Margulis J, Salazar L,Mao K, Lau AL, Yeung SY, Humbert S, Saudou F, Klionsky DJ, Finkbeiner S, Zeitlin SO, Marsh JL, David E. Housman DE, Thompson LM, & Steffan JS*. (2014) Potential function for the Huntingtin protein as a scaffold for selective autophagy.PNAS.111(47):16889-94
7.Jin N,Mao K, Jin Y, Tevzadze G, Kauffman EJ, Park S, Bridges D, Loewith R, Saltiel AR, Klionsky DJ, & Weisman LS*. (2014) Roles for PI(3,5)P2 in nutrient sensing through TORC1.Mol. Biol. Cell25(7):1171-85
8.Mao K#, Liu X#, Feng Y, & Klionsky DJ* (2014) The progression of peroxisomal degradation through autophagy requires peroxisomal division.Autophagy10(4):652-61 (# equal contribution)
9.Mao K, Chew LH, Inoue Y, Cheong H, Nair U, Popelka H, Yip CK, & Klionsky DJ*. (2013) Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation.PNAS.110(31):E2875-84
10.Mao K, Wang K, Liu X, & Klionsky DJ*. (2013) The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy.Dev. Cell26(1):9-18
11.Kaiser SE,Mao K, Taherbhoy AM, Yu S, Olszewski JL, Duda DM, Kurinov I, Deng A, Fenn TD, Klionsky DJ, & Schulman BA*. (2012) Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.Nat. Struct. Mol. Biol.19(12):1242-9
12.Wang K, Yang Z, Liu X,Mao K, Nair U, & Klionsky DJ*. (2012) Phosphatidylinositol 4-kinases are required for autophagic membrane trafficking.J. Biol. Chem.287(45):37964-72
13.Mao K, Wang K, Zhao M, Xu T, & Klionsky DJ*. (2011) Two MAPK signaling pathways are required for mitophagy inSaccharomyces cerevisiae.J. Cell Biol.193(4):755-67
14.Kanki T, Wang K, Baba M, Bartholomew CR, Lynch-Day MA, Du Z, Geng J,Mao K, Yang Z, Yen WL & Klionsky DJ*. (2009) A genomic screen for yeast mutants defective in selective mitochondria autophagy.Mol. Biol. Cell20(22):4730-38.
15.Liu C,Mao K, Zhang M, Sun Z, Hong W, Li C, Peng B, & Chang Z*. (2008) The SH3-like domain switches its interaction partners to modulate the repression activity of mycobacterial iron-dependent transcription regulator in response to metal ion fluctuations.J. Biol. Chem.283(4):2439-53.
五、招生学科
生物学（生物医学）
六、博士后招聘
我们实验室长期招聘博士后（非讲师）。有意向者，请与我联系maokai@nwafu.edu.cn。
